Posted on Wednesday 14 December 2011
The QS World University Rankings is a ranking of the world’s top 700 universities by Quacquarelli Symonds using a method that has published annually since 2004.

The QS rankings were originally published in publication with Times Higher Education from 2004 to 2009 as the Times Higher Education-QS World University Rankings. In 2010, Times Higher Education and QS ended their collaboration. QS assumed sole publication of the existing methodology, while Times Higher Education created a new ranking methodology, published as Times Higher Education World University Rankings.

Rank School Name Country Size Research Focus Score
1 Massachusetts Institute of Technology (MIT) United States M VH CO 100.00
2 Stanford University United States L VH FC 83.00
3 University of California, Berkeley (UCB) United States XL VH FC 83.00
4 University of Cambridge United Kingdom L VH FC 73.00
5 California Institute of Technology (Caltech) United States S VH CO 68.00
6 Imperial College London United Kingdom L VH FC 67.00
7 The University of Tokyo Japan L VH FC 64.00
8 ETH Zurich (Swiss Federal Institute of Technology) Switzerland L VH FO 62.00
9= National University of Singapore (NUS) Singapore XL VH FC 59.00
9= University of Oxford United Kingdom L VH FC 59.00
11 Tsinghua University China L VH FC 58.00
12 Carnegie Mellon University United States M VH FC 55.00
13 Georgia Institute of Technology United States L VH CO 54.00
14 University of Toronto Canada XL VH FC 54.00
15 University of California, Los Angeles (UCLA) United States XL VH FC 53.00
16 University of Illinois at Urbana-Champaign United States XL VH FC 53.00
17 Kyoto University Japan L VH FC 50.00
18 Delft University of Technology Netherlands L VH FO 49.00
19= Cornell University United States L VH FC 46.00
19= University of Michigan United States XL VH FC 46.00
21 Princeton University United States M VH CO 45.00
22 Harvard University United States L VH FC 45.00
23 Tokyo Institute of Technology Japan M VH FO 45.00
24 KAIST - Korea Advanced Institute of Science & Technology Korea, South M VH CO 44.00
25 The University of Manchester United Kingdom XL VH FC 44.00
26 The Hong Kong University of Science and Technology Hong Kong M VH CO 43.00
27 University of Texas at Austin United States XL VH FC 43.00
28 Purdue University United States XL VH FC 43.00
29 McGill University Canada L VH FC 43.00
30 University of British Columbia Canada XL VH FC 42.00
31 Ecole Polytechnique Fédérale de Lausanne Switzerland M VH FO 42.00
32 The University of Melbourne Australia XL VH FC 42.00
33 Peking University China L VH FC 41.00
34 University of California, San Diego (UCSD) United States L VH FC 41.00
35 École Polytechnique France S VH CO 39.00
36= Nanyang Technological University (NTU) Singapore L VH CO 39.00
36= Technische Universität München Germany L VH FO 39.00
38 Seoul National University Korea, South L VH FC 38.00
39= Rheinisch-Westfälische Technische Hochschule Aachen Germany XL HI FC 38.00
39= University of Waterloo Canada L VH CO 38.00
41 National Taiwan University (NTU) Taiwan XL VH FC 38.00
42 The University of New South Wales Australia XL VH FC 38.00
43 Shanghai Jiao Tong University China L VH FC 37.00
44 The University of Sydney Australia XL VH FC 37.00
45 Australian National University Australia M VH CO 36.00
46 University of Edinburgh United Kingdom L VH FC 36.00
47 Indian Institute of Technology Bombay (IITB) India M VH CO 35.00
48 Technische Universität Berlin Germany L VH CO 35.00
49 Universität Karlsruhe Germany L VH CO 34.00
50 Eindhoven University of Technology Netherlands M VH FO 34.00 

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Posted on Tuesday 13 December 2011
ISS Flight Control Room 2006

Images above: The above photos show the flight control room known as FCR-1 as it appeared back in 1968, and as it debuts this week as the main center for flight control of the International Space Station. Photo credit: NASA

International Space Station flight controllers are now operating from the new mission control room. The new station room was first commissioned as one of two flight control rooms at Johnson Space Center in 1965. It has been updated to increase technical capabilities and available workspace for the station team as they embark on a series of tasks as complex as any in the history of human spaceflight.

Station flight controllers relocated Oct. 7 to the new control room, which has 20 consoles, liquid crystal displays, three giant display screens and more space in general for safety and comfort. 

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The Indian Institutes of Technology (Hindi: भारतीय प्रौद्योगिकी संस्थान, IITs) are a group of autonomous engineering  and technology-oriented institutes of higher education. The IITs are governed by the Institutes of Technology Act, 1961 which has declared them as “institutions of national importance”, and lays down their powers, duties, framework for governance etc.[1]  They were created to train scientists  and engineers, with the aim of developing a skilled workforce to support the economic and social development of India. IITs are listed as societies under the Indian Societies Registration Act.

The 1961 act lists seven institutes, which are, in order of establishment, IIT Kharagpur in Kharagpur (1950; as IIT 1951[2]), IIT Bombay in Mumbai (1958), IIT Madras in Chennai (1959), IIT Kanpur in Kanpur (1959), IIT Delhi in New Delhi (1961; as IIT 1963), IIT Guwahati in Guwahati (1994) and IIT Roorkee in Roorkee (1847; as IIT 2001).

In addition to the seven IITs, the Institutes of Technology (Amendment) Act, 2010 seeks to add nine new institutes to the list. Of these, eight are new institutes, in order of establishment, IIT Ropar in Rupnagar (2008), IIT Bhubaneswar in Bhubaneswar (2008), IIT Gandhinagar in Gandhinagar (2008), IIT Hyderabad in Hyderabad (2008), IIT Patna in Patna (2008), IIT Rajasthan in Rajasthan (2008), IIT Mandi in Mandi (2009) and IIT Indore in Indore (2009).[3] These IITs are registered as societies and are in various stages of consolidation and development.[4] The ninth is Institute of Technology, Banaras Hindu University (IT-BHU), which is currently a faculty under the administration of Banaras Hindu University, Varanasi, which is to be named "Indian Institute of Technology (Banaras Hindu University), Varanasi",[3] which is to be abbreviated IIT-BHU.[5] The bill was approved by the Indian Cabinet in February 25, 2011,[6] and the Lok Sabha passed the bill on March 24, 2011.[7] It is still to be adopted by the Rajya Sabha.

Each IIT is an autonomous university, linked to the others through a common IIT Council, which oversees their administration. They have a common admission process for undergraduate admissions, using the very selective Indian Institute of Technology Joint Entrance Examination (IIT-JEE), which in 2011 had an acceptance rate of less than 1 in 50 (485,000 candidates and only 9,618 seats). Undergraduate students will eventually receive a B. Tech. degree in Engineering. The graduate level program that awards M. Tech. degree in engineering is administered by the older IITs (Kharagpur, Bombay, Madras, Kanpur, Delhi, Guwahati, Roorkee) and the Indian Institute of Science, Bangalore. M. Tech. admissions are done on the basis of the Graduate Aptitude Test in Engineering, (popularly known as GATE test). In addition to the B. Tech. and M. Tech. programs that IITs are mostly known for, IITs also award other graduate degrees such as M.S. in engineering, M.Sc in Math, Physics and Chemistry, MBA and Ph.D. through tests such as Common Admission Test (CAT), Joint Admission Test to M.Sc. (JAM) and Common Entrance Examination for Design (CEED). About 15,500 undergraduate and 12,000 graduate students study in the IITs, in addition to research scholars.

IIT alumni have achieved success in a variety of professions.[8] Most of the IITs were created in early 1950s and 1960s as the Institutes of National Importance through special acts of Indian Parliament. The success of the IITs led to the creation of the Indian Institutes of Information Technology (IIIT) in the late 1990s and in the 2000s.


Institutes

The IITs are located in:









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World Top 100 Engineering Colleges:
These are the list of best 100 engineering institutes all over world. Aspirants preparing for engineering entrance in all over world, Plz go through & chosse which will make of your dream comes true... although all are very prestigious one.
     
1. Massachusetts Institute of Technology (MIT) United States 100.0
2. University of California, Berkeley United States 93.9
3. Stanford University United States 85.3
4. California Institute of Technology (Caltech) United States 81.6
5. University of Cambridge United Kingdom 76.2
6. Carnegie Mellon University United States 71.6
7. Imperial College London United Kingdom 70.9
8. Georgia Institute of Technology United States 68.9
9. University of Tokyo Japan 67.4
10. University of Toronto Canada 66.0
11. National University of SINGAPORE(NUS) Singapore 64.5
12. Tsinghua University China 63.4
13. Eth Zurich (Swiss Federal Institute of Technology) Switzerland 63.1
14. University of Oxford United Kingdom 61.6
15. Princeton University United States 61.5
16 University of California, Los Angeles (UCLA) United States 61.4
17. Delft University of Technology Netherlands 60.4
18. Mcgill University Canada 60.1
19. Harvard University United States 59.6
20. University of Illinois United States 58.4
21 Tokyo Institute of Technology Japan 57.0
22 Kyoto University Japan 56.8
22 University of British Columbia Canada 56.8
24 Cornell University United States 56.4
24 Hong Kong University of Science & Technology Hong Kong 56.4
26 Nanyang Technological University Singapore 55.2
27 University of New South Wales Australia 54.7
28 The University of Melbourne Australia 54.4
29 Technion - Israel Institute of Technology Israel 54.1
30 University of Waterloo Canada 53.9
31 École Polytechnique France 52.6
32 University of Texas at Austin United States 52.0
33 Purdue University United States 50.9
34 Kaist - Korea Advanced Institute of Science & Technology Korea, South 50.5
35 University of California, San Diego United States 50.3
36 Australian National University Australia 49.9
36 Indian Institute of Technology Bombay (IIT Bombay) India 49.9
38 Peking University China 49.2
38 University of Michigan United States 49.2
40 Technische Universität München Germany 48.7
41 The University of Sydney Australia 48.0
42 Indian Institute of Technology Delhi (IIT Delhi) India 47.7
43 Seoul National University Korea, South 46.0
44 Ecole Polytechnique Fédérale de Lausanne Switzerland 45.2
45 University of Manchester United Kingdom 44.8
46 University of Alberta Canada 44.6
47 Monash University Australia 44.3
48 Shanghai Jiao Tong University China 43.8
49 Eindhoven University of Technology Netherlands 42.3
49 National Taiwan University Taiwan 42.3
49 Osaka University Japan 42.3
49 University of Science and Technology of China China 42.3

53 Texas A&M University United States 41.8
54 Kth, Royal Institute of Technology Sweden 41.5
55 Chalmers University of Technology Sweden 41.3
56 Katholieke Universiteit Leuven Belgium 40.8
56 The University of Auckland New Zealand 40.8
58 Yale University United States 40.7
59 Virginia Polytechnic Institute (VIRGINIA TECH) United States 40.4
60 University of Edinburgh United Kingdom 40.2
61 University of Queensland Australia 40.0
62 University of California, Santa Barbara United States 39.8
63 Columbia University United States 39.5
63 Politecnico di Milano Italy 39.5
65 Technische Universität Berlin Germany 39.3
66 Rensselaer Polytechnic Institute United States 38.7
67 Johns Hopkins University United States 38.5
68 Universität Stuttgart Germany 38.0
69 University of Hong Kong Hong Kong 37.3
70 Indian Institute of Technology Kanpur (IIT Kanpur) India 37.1
70 Rheinisch-Westfälische Technische Hochschule Aachen Germany 37.1
72 Universität Karlsruhe Germany 37.0
73 University of WISCONSIN-Madison United States 36.9
74 Indian Institute of Technology Madras (IIT Madras) India 36.0
74 The Chinese University of Hong Kong Hong Kong 36.0
76 Vienna University of Technology Austria 35.9
77 Technical University of Denmark Denmark 35.8
78 University of Pennsylvania United States 35.0
79 Mcmaster University Canada 34.9
79 Pennsylvania State University United States 34.9
81 Northwestern University United States 34.6
81 University of Maryland United States 34.6
83 Indian Institute of Technology Kharagpur (IIT Kharagpur (IIT-KGP) India 34.5
83 University of Chicago United States 34.5
85 University of Washington United States 34.3
86 Chulalongkorn University Thailand 34.0
87 Université de Montréal Canada 33.9
87 University of Southern California United States 33.9
89 City University of Hong Kong Hong Kong 33.7
90 Bandung Institute of Technology Indonesia 33.5
90 University of Calgary Canada 33.5
92 Fudan University China 33.2
93 Brown University United States 33.1
94 Helsinki University of Technology Tkk Finland 33.0
94 Rmit University Australia 33.0
96 Ucl (University College London) United Kingdom 32.8
96 University of Southampton United Kingdom 32.8
98 Tohoku University Japan 32.7
98 University of Birmingham United Kingdom 32.7
100 École Normale Supérieure, Paris France 32.4 

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A list of the best technical colleges for technical careers students is put out annually by PC Magazine, with input provided by The Princeton Review. The assessments include factors such as availability of information online, hardware and software provided by the university, lab facilities, student organizations. Basically, the three main areas of focus were academics, student resources and campus connectivity. The top technical colleges are listed below.

1. Villanova University

Villanova University tops the PC Magazine list of best colleges for technical careers. Located in Villanova, PA, the private college provides new laptops for all students(included in tuition), tech support calls with guaranteed 24-hour turnaround time, and state of the art labs and student programs. Students can perform many activities online, including registering for classes, accessing the library to receive reading assignments, downloading lectures (or receiving them via podcast), taking exams, submitting papers, and receiving grades. Tuition is approximately $29,000 per year.
 

2. MIT

The Massachusetts Institute of Technology is one of the best known technical colleges around. It has its own operating system (a unix based desktop interface called Athena) and the campus is completely wireless, with over 3000 wireless access points. The university's OpenCourseWare system provides course materials on the Web, free of charge, to any user in the world. Over 80 percent of MIT's faculty participates, and over 1,400 courses are available on the system. MIT is known for letting their students have free reign over "teching out" their dorms - which has resulted in an emergency pizza button (push for a Dominoes deliver) as well as many other amazing additions. Cost is approximately $34k per year.

3. Indiana University, Bloomington

Indiana University Bloomington has won awards and numerous industry accolades for their research and technology offerings. The school owns the fastest university-owned supercomputer, and they have agreements in place with the larger software vendors to make applications available to the students at little or no cost. The school is a leader in the open-source software community. In addition, their online portal, called Oncourse, allows students to check grades and scheduling information and allows teachers to post comments to students and vice versa. Students can also communicate with each other via Oncourse, asking questions and discussing topics virtually. Cost is approximately $19k out of state and $6k in state.

4. Swarthmore College

Located in Swarthmore, PA, the college offers dedicated computing services throughout the campus. The dorms have recently gone wireless, and there is 24/7 tech support. Many professors use Blackboard software to distribute assignments and host forums for discussions.Student run computer society manages a media lounge and video pit, among other things.Cost is approximately $32,000 per year.

5. Creighton University

Located in Omaha, NE, Creighton is the first school to notify students via text message of their acceptance. They host a huge, annual Gamefest, which has drawn big name sponsors. Creighton offers small class sizes and over 50 IT related majors and courses in technology and leadership. Several courses are avilable via podcast. The school is currently researching and testing the ability to have applications delivered via cellular networks, which would enable students can get their grades, register, take quizzes, and more from their cell phones.

6. University of Illinois

The University of Illinois has some very big entrepreneurial names among its alumni. The school feels that the environment - one where calculated risk taking is encouraged and rewarded - plays a big role in this. The University is the birthplace of the first web browser and the first parallel supercomputer. Some of the highlights of the program:
  • On campus Apple and Dell stores, with student discounts.
  • Extensive wireless connectivity.
  • Video games and consoles for rent int he library
  • 600MB of free online storage space
Tuition for the University is approximately $7000 per year in-state and just over $21,000 per year out of state.

7. Michigan Tech University

Michigan Technological University is a small school in the town of Houghton, MI. With approximately 5500 students, the program places a large value on student involvement. There is also a big emphasis on real world education. One example of this is the University's Blue Marble program - students form corporations, which are structured to mimic corporations in the real world. The corporations then receive grants from companies in order to solve real world problems.

The campus has made a lot of investments recently in technology including wireless networking, smart white boards, podcast lectures and 24 hour secure access to computer labs.
Cost per year is approximately $7500 per year in-state and just under $19,000 per year out of state.

8. University of Southern California

USC is on the cutting edge of technology availability for students. The school has one of the fastest supercomputers, which students can schedule research time on and access from ports all over the campus. They also offer hundereds of wireless access points, and hundreds of classrooms are set up with webcams and microphones. There is an onlince course management system, called Blackboard, that allows professors to post lectures and review notes online.
All that cool technology comes at a price - the annual tuition is approximately $34,000.

9. Quinnipiac University

Located in CT, Quinnipiac is a wired university, with a majority of classes requiring online communications through their own Blackboard system. All incoming students are required to purchase a laptop, and the university checks the freshman students laptop configuration to make sure it will work with their wired campus. Students are also able to stay connected via a Windows Mobile PDA. The university recently partnered with Rave Wireless to allow students access to things like academic info, shuttle-bus locations, class and group messages, and text messages.
Tuition is just over $25,000 per year.

10. The University of Oklahoma

The University of Oklahoma offers a user-friendly communication and learning platform called Desire2Learn, which allows for online access to lectures and notes, and also facilitates discussions with chat systems that connect the students with the professors. The University also offers students their own Sooner Account, which allows them to stay in contact with each other and includes a bunch of services, with access to research, the ability to legally download movies and music, 1 GB of online storage space per student, and free web space. They also offer the students access to thousands of Dell computers through lots of wireless access points in the university.
Tuition is $3000 per year in-state and $11,000 per year out of state.
 
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In 1958, President Eise­n­hower signed the Space Act, officially creating the National Aeronautics and Space Administration. From the beginning, the purpose for the ne­w branch extended beyond space ships and moon boots. The law stipulated that its research and advancements should benefit all people, and in its 50-year history, NASA has certainly fulfilled that role.

Although most people today will never set foot on the moon, everyone likely comes in contact with a NASA by-product every day. Partnering with various research teams and companies, NASA continues to spawn a vast array of new technologies and products that have improved our daily lives. Basic steps in health, safety, communications and even casual entertainment find their ro­ots in the government branch commonly associated with rocket ships and floating people. In fact, NASA has filed more than 6,300 patents with the U.S. government [source: NASA Scientific and Technical Information].
Each year since 1976, NASA has published a list of every commercialized technology and product linked to its research. The NASA journal "Spinoff" highlights these products, which have included things like improved pacemakers, state of the art exercise machines and satellite radio. Each product was made possible thanks to a NASA idea or innovation.
But it doesn't take a rocket scientist to use many of these so-called spinoffs. Read on to learn about ten of these familiar products.

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Gamma-rays are the highest-energy form of light in the universe. Some are generated by transient events, such as solar flares and the huge star explosions known as supernovas. Others are produced by steady sources like the supermassive black holes at the hearts of galaxies.


NASA's Fermi Gamma-ray Space Telescope has been mapping out the high-energy sky since its June 2008 launch. Earlier this year, the Fermi team released its second catalog of sources detected by the instrument's Large Area Telescope (LAT), producing an inventory of 1,873 objects shining in gamma-ray light.
Fermi scientists recently compiled a "top 10 list" to mark the occasion, and to highlight the diversity of gamma-ray sources. Five of the sources on the list are found within our own Milky Way, while the other five reside in distant galaxies.


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Show me your scientists, and I'll tell you your future. By this measure, Tennessee is in good hands. Without fanfare, our state has amassed a scientific community worthy of celebration. Hidden away in laboratories from Kingsport to Memphis, they are paving the way to Mars and beyond, fighting AIDS, preserving endangered species and gleaning information from the dead.
It’s not easy to rank the scientists working in such diverse fields as neuroscience, nuclear physics, geology and forensic research, so fortunately, a comprehensive listing and qualitative ranking was not our goal. What lies before the reader is a sampling of some of the most prolific, accomplished, as well as up-and-coming scientists among us. Looking at the these ten scientists affirms an image of Tennessee as a state steadily moving from its agricultural past towards the cutting-edge research and development frontiers of tomorrow.
Many of the scientists on the list have settled here after meandering journeys across the globe. Taking jobs at Eastman Chemical, Oak Ridge National Laboratory, St. Jude Children’s Research Hospital, Vanderbilt University and elsewhere, they have boosted the national and even international reputations of those organizations. Some of them should be credited with drawing to our state scores of younger scientists seeking inspiration and guidance through proximity and mentorship. This list should serve as a reminder: Our health, as well as the health of our state's economy, may well depend on the scribbled formulas, computer models and incipient test tube miracles in our laboratories right now.
Slingshots and Robots
Steve Canfield
Associate Professor of Mechanical Engineering
Tennessee Technological University
For Steve Canfield, a 34-year old associate professor of mechanical engineering at Tennessee Tech in Cookeville, working on a demanding project for NASA doesn't mean his mind is always lost in space. On top of creating a new source of energy for orbiting spacecraft, Canfield finds time to delve into earthly matters, such as building robots to clean up dangerous industrial sites and putting together equipment for disabled children.
Canfield is the leading researcher in Tennessee on devising a method to apply Earth¹s magnetic force to boost various types of spacecraft as they orbit our planet. NASA qualifies Canfield¹s work as high-risk but high-payoff because it marries two new concepts of alternative energy in space. While traditional rockets push against their own exhaust, Canfield is convinced that electrodynamic tethers could shove a spacecraft against the Earth's magnetic field, transferring the rotational angular momentum of the Earth to the orbital angular momentum of the spacecraft. In order to eliminate reliance on current methods of boosting rockets into space and helping them stay in orbit, Canfield hopes to merge the tethers, which collect magnetic energy from the Earth¹s ionosphere but cannot rise above a certain limit, with momentum exchange tethers, which conduct this energy to a spacecraft. With such technology, one could essentially drive a rocket forever in space, feeding off magnetic forces of surrounding planets.
Canfield’s colleagues hail him as the youngest among the brightest scientists in Tennessee. But he doesn¹t hear those compliments often because when his mind is not wrapped around finding energy in space, it designs robots that would replace humans in cleaning up industrial sites. With a few patents already pending, Canfield believes that in 10 to 15 years disposable robots will perform surgeries, clean up boilers at power plants and help examine contaminated areas.
Between working on those projects and teaching classes at Tennessee Tech, Canfield also guides his students in the building of equipment for children suffering from dwarfism, cerebral palsy and other ailments. In the process, Canfield grooms students to become caring citizens on Earth who are capable of taking his research beyond the Earth¹s orbit. Up, up and away.
The Best Offense...
Peter Doherty
Infection & Host Defense Program
St. Jude Children¹s Research Hospital
Peter Doherty found the hit man of the immune system‹a killer T-cell that attacks viruses and destroys them. The discovery earned Doherty and Swiss scientist Rolf Zinkernagel their 1996 Nobel Prizes in Physiology or Medicine.
To be exact, Doherty and Zinkernagel discovered cell-mediated immune defense, or the way white blood cells recognize and kill virus-infected cells. Their findings lit the way to change the immune system in cases when it fails to respond sufficiently to invading microorganisms or cancer metastasis. The knowledge of the inner defenses of the immune system also allows doctors to diminish or change unwanted immune reactions towards the body¹s own tissue, such as those occurring in rheumatic diseases.
Today Doherty, a native of Brisbane, Australia, labors to further understand immune defenses at St. Jude Hospital in Memphis, where he landed after a long chain of scientific appointments around the world. Such is his reputation that Doherty himself is now a magnet drawing other acclaimed scientists to St. Jude.
When Doherty and Zinkernagel began their research in the late 1960s and early 1970s, researches already knew how antibodies, the circulating defense molecules, recognize and kill foreign bacteria. It was not clear how white blood cells recognize and kill virus-infected cells without destroying the normal uninfected cells.
Doherty’s work made it possible to understand that the true function of transplantation antigens is not to provide an obstacle to transplantation. Instead, their function is to bind themselves to viral molecules and inform white blood cells as to whether they should become aggressive or remain inactive toward the virus. Consequently, it became clear that each individual, thanks to his or her unique set of transplantation antigens, also carries his or her unique immune system.
As Doherty toured the United States giving his first talks on T-cells in the 1970s, “those ideas both contradicted the accepted North American model for the role of immune response genes and turned the perception of the transplantation system on its head,” he recalled in his Nobel speech. “Many people have told me years later that they heard this seminar, came away with the sense that the findings were significant, but did not fully grasp the import. Evidently some were also infuriated by what we were saying.”
At 63, Doherty jokes that he should be doing age research instead of working in pediatrics. He has high hopes for St. Jude, “a great institution” that has the talent to find a cure for AIDS and other ailments.
“Ideas interest me. Intellectually, I march to the beat of my own drum and have little interest in competing in races. There are too few people working in the area of viral pathogenesis and immunity, too little funding, too many problems and too little time.”
Knoxville’s Noah
Lou Gross
Professor of ecology, evolutionary biology and mathematics
University of Tennessee, Knoxville
The endangered spray toad living in a Tanzania waterfall and the rare Florida panther that roams the Everglades have one thing in common: Lou Gross may be the last hope for them both.
At UT-K since 1979, Gross is the mastermind behind elaborate computer models of environment now gaining popularity across the world. Using data from satellites and radio collars that track animals and survey landscapes, Gross logs the information into computer networks and builds replicas of real-life environments to save endangered populations and record human impact on the environment.
But you¹d hardly peg Gross as a species-preserving Noah of the Twenty-first Century when you see him working as sound engineer at Knoxville¹s Laurel Theatre or producing folk music shows at the local WUOT-FM. Hanging with people like Bob Douglas, the legendary fiddler who gave his last concert at Laurel at the age of 100, Gross says he gains inspiration for his environmental endeavors. He¹s also been known to perform the occasional Cajun and contra dance.
In his research, the 52-year-old Philadelphia native works with UT-K’s acclaimed computer whiz Jack Dongarra, builder of an intra-campus computer grid that allows South Florida specialists to transfer sample data from the Everglades to Gross in Knoxville. Before the grid, the specialists had to ship data via overnight delivery.
“It's a great age to combine computational science with biology,” Gross says.
Since he began his work at the Institute for Environmental Modeling in the late 1980s, such high profile entities as the National Science Foundation, the Army Corps of Engineers and the Environmental Protection Agency have used Gross’ work in protecting the environment. In South Florida alone, Gross led the way in efforts to save the Florida panther, the Everglades kite, the wood stork, not to mention their prey‹deer, snails and fish. Gross’ models allow groups of scientists to track, for example, levels of water in the Everglades to restore the natural patterns of water exchange, which is crucial to survival of many species. “Even in the short term, the Everglades models we produced directly affected planning for removing canals and changing the way the water flows in South Florida,” Gross says.
Aside from computational ecology, Gross’ group has developed a program for the Nuclear Regulatory Commission to sample soil cores and determine levels of contamination in a radioactive field.
In late January, Gross traveled to a World Bank meeting on behalf of the Tanzanian government to discuss the effects on the environment produced by the dam that supplies one-third of the electricity in the African country. At the meeting, Gross literally stood out as the last hope of survival for the Kihansi Spray Toad, whose environment was affected by the construction of the dam. Gross’ models might pave the way to restore the toad’s environment elsewhere.
The Clock is Ticking
Julia Hurwitz
HIV Vaccine Development
St. Jude Children¹s Research Hospital
Today, 43 million people are infected with AIDS. Every day, 8,000 of the infected HIV patients die, which totals three million deaths a year. In other words, a population equal to three cities the size of Memphis get completely wiped out by HIV each year. Against this backdrop, it’s easy to see why Julia Hurwitz feels a sense of urgency about her job as an AIDS vaccine researcher at St. Jude. And when Hurwitz says there is something wrong with the system, the opinion comes from long, studied involvement, not hasty conclusion.
The system in question is the drug approval process in the United States. Currently, she says, the country is too fearful of taking risks in testing new medicines‹risks it took without flinching while developing the medicines of today.
In charge of researching an AIDS vaccine at St. Jude, Hurwitz has seen firsthand how nimble and evasive the virus can be, and how ponderous and rigid the United States’ drug testing and approval process is in comparison.
Currently, Hurwitz and clinician Karen Slobod are the principal investigators in the development of a promising vaccine cocktail that will combine the qualities of two different cells in the immune system to ward off the AIDS virus. Early on, Hurwitz saw that all the researchers working on AIDS vaccines across the world were concentrating too much on single-cell approaches, without tapping the multiple defense layers of the immune system. But since HIV can attack on multiple fronts, it’s important that vaccines defend on multiple fronts as well.
Hurwitz says a significant obstacle to HIV vaccine development lies in the remarkable diversity of envelope proteins, the major targets of neutralizing antibodies. Nonhuman primate studies showed that single-envelope vaccines have protected against only a small percentage of viral challenges. Similarly, in clinical trials, single-envelope vaccines have failed to prevent break-through infections when challenge viruses were inevitably mismatched with the vaccine. To protect humans from infection by any isolate of HIV, Hurwitz and her group began preparing vaccine cocktails combining multiple envelopes from distinct viral isolates. Testing several methods of vaccine delivery in small animals has shown that successive immunizations with the so-called envelope can trigger a strong response from the neutralizing antibody. The promise of this system has led to the initiation of clinical trials, which will ultimately show whether cocktail vaccines would prevent human HIV infections.
For any optimism this development might present, Hurwitz offers a cautionary example. As daunting a foe as the HIV virus has proven to be, the ultimate challenge may lurk in regulatory morass that awaits even the most promising research. “We¹ve come 80% of the way, but the last 20% may be tough,” Hurwitz says. She knows firsthand just how much the final 20% can slow the process.
In one of Hurwitz’s earlier research triumphs—the discovery of a parainfluenza vaccine that attacks a virus causing babies to turn blue—the process was as far along as the FDA-approved animal trials for the vaccine. The testing went perfectly—the animals injected answered negative; the ones that were not registered positive. It was 1996. More than seven years later, the clinical trials of the vaccine are just now gaining momentum. Translate that pace of regulatory process to Hurwitz’s current work, with three million lives each year held in the balance. It doesn’t take a mathematician to add up the cost.
The Mind¹s Eye
Jon Kaas
Professor, Psychology & Cell Biology
Vanderbilt University
In the 1960s, long before the term neuroscience was coined, Kaas discovered that processing visual stimulation takes up one-third of the brain’s activity in humans. Prevailing opinion at the time didn¹t support Kaas’ discovery. So much for prevailing opinion.
When Kaas started his research on the brain in primates, “everything was terra incognita,” says one colleague. “Today, you don¹t open the textbook in neuroscience without seeing Jon¹s name.”
Mapping of the visual cortex of the brain allowed Kaas to better understand how the brain processes information it receives from the eyes, ears and skin, and how it controls the motion of arms, legs and other muscle systems. By Kaas’ own estimation, humanity is now able to understand 25-50% about its collective brain. Considering that 100 years ago the figure hovered around 1%, Kaas is looking excitedly at ways his discoveries will augment treatment of brain injuries.
Twenty years ago, scientists were convinced that after a certain age the neurons in human brains stopped making new connections, or, in the vernacular, the brain was “losing neurons,” causing mental abilities to decline in adults. But Kaas and his research group proved that the adult brain is capable of forming new connections, especially in response to severe trauma or injury. That insight had caused a major change in the way medical researchers view brain injuries, giving clues to ways in which the human brain can restore itself, with the help from doctors, of course, from very few existing connections.
At 66, Kaas brings in half a million dollars in research funding a year to Vanderbilt and has no intention of slowing down anytime soon. More than anyone else, Kaas understands the dangers of slowing down. He has seen too many people deteriorate quickly and lose cognitive functions upon retirement, having made the decision to switch to a “simpler” lifestyle. Gaining inspiration from people like actor Christopher Reeve, Kaas advocates constant brain workouts. For himself, once the grants run out and retirement looms, Kaas has reserved writing about science, traveling and indulging in basketball. Currently, he gets together with Vanderbilt colleagues to shoot hoops roughly once a week.
While Kaas’ friends think his work deserves recognition similar in stature to the Nobel Prize, they say his lack of a self-promoting instinct hurts his chances. Kaas admits that neuroscience doesn’t lend itself easily to consideration for the Nobel award, yet he is thankful for the recognition he has received so far.
An accomplished professor at a prestigious institution and member of the National Academy of Sciences, Kaas is still considered a renegade. He is now busy resurrecting a particular area in brain research that was “swept under the rug” decades ago for reasons of convenience. Very few textbooks include this aspect of his research, but he soldiers on because, he says, if you don’t prove your own theory wrong, your students will. To Kaas, the best thing about science is the “ability to change your own thinking and change the thinking of others.”
Red Rover, Red Rover…
Harry “Hap” McSween
Earth and Planetary Scientist
University of Tennessee, Knoxville
No one knows when the first humans will touch down on Mars, but for the past month Hap McSween has been able to consider the red planet a second home. From NASA’s Jet Propulsion Laboratory in Pasadena, Calif., McSween has been planning strategy for the second rover, Opportunity, which landed on Mars at the end of January. Along with the other scientists under his command, McSween has been living on Mars time, where days are 40 minutes longer than on Earth.
Those 40-minute increments do add up, but McSween has labored tirelessly on NASA’s ongoing Mars mission, whose primary objective is to find whether there was enough water on Mars to support evolution.
The 58-year-old McSween has been involved with Mars long before NASA¹s current missions. He was one of the first scientists to discover pieces of Martian rocks in meteorites that fell to Earth. For the past 25 years, he studied those rocks and concluded they could indeed have been hurled from Mars’ surface at a speed of five kilometers an hour if they were hit by another meteor. First widely criticized, that theory gained credibility over time and it is now accepted that some of the meteorites found on Earth’s surface are souvenirs from Mars.
McSween attributes his passion for geology to his uncle, who used to send him samples of rocks and thus fired up a passion for science in the eight-year-old boy. “My uncle wasn’t a scientist. He was a retired businessman in New Jersey, but his hobby turned into a consuming career for me,” says McSween, saddened that his uncle never saw the fruits of his hobby expand to inter-planetary dimensions.
While McSween is focusing on orchestrating the research efforts of Opportunity, he was largely responsible for the selection of the Gusev crater, the landing spot for Spirit, the first rover that landed there as part of the current mission. It was Spirit that sent 3,000 startling images from Mars back to Earth in the first couple of days of its operation. McSween, his aide Jeff Moersh and four of his graduate students used the data from Mars orbiters to map out a landing site that NASA first considered a risky spot due to high winds, until McSween’s research convinced them otherwise.
A former jet pilot and Vietnam veteran, McSween doubts that there is extraterrestrial life on Mars, but he knows that Mars is the most Earth-like planet in our system, and therefore is the best place to look for signs of life that could have existed.
To McSween, space research is undeniably vital to the United States and the world. “There are plenty of financial bonuses that come from technological development, but the main benefit we derive from these space missions is the effect they have on our children.”
Studying the Earth and Mars is fascinating to McSween, who views them as grand geologic laboratory experiments that have run four-and-a-half-billion years. Being able to research another planet under a different set of conditions gives us an opportunity to avoid harming our own blue planet, and for McSween, is a child’s dream come true.
Framing Symmetries
Alexander Olshanskiy
Professor, Mathematics (Group Theory)
Vanderbilt University
To say Alexander Olshanskiy walks to work most of the time doesn’t tell you much about him. But look at it from his perspective—he walks five kilometers from his home to his office at Vanderbilt University, with an average velocity of seven kilometers per hour, adjusting for shortcuts and the occasional ride from his wife in inclement weather—and it’s easier to figure out his occupation.
Heir to the Einstein-influenced tradition of the distracted theoretical mathematician, Olshanskiy is considered the strongest group theorist alive today. He was lured to Vanderbilt in 1999 from Moscow State University in Russia, where he went to school and later became a professor on the mathematical faculty. Listening to Olshanskiy tell it, there was no real plan. Arriving in Moscow from the small Russian town of Saratov (where he grew up in a family of mathematicians), he attended some courses in theoretical math and just “went with the flow.” At 23, Olshanskiy was invited to deliver a plenary talk at the 1969 national conference before 500 renowned scientists. A year later he was awarded the prize of the Moscow Mathematical Society. As the years have progressed, his group theory work has gained more recognition, and the honors have multiplied, though one would be hard-pressed to find evidence of this in his workplace. His office is Spartan: a couple of chairs, a blackboard, a desk with a small pile of papers on the side and a blank sheet of paper in the middle. A family picture on the wall—his wife is also a mathematician, as are their two sons.
Such a simple workspace in which to work on such a complicated theory. Group theory deals with multiplication of symmetries out of which groups of symmetries are born. Olshanskiy and his colleagues are now assessing the complexities of calculations in those groups. For a better sense of its complexity, just look at the title of an article recently co-authored by Olshanskiy: “Non-amenable finitely presented torsion-by-cyclic groups.” That’s a mouthful, and don’t ask Olshanskiy to explain group theory in layman’s terms; he’ll say that he would need the courage of a populist to alter the truth of the matter, and he doesn’t have that courage.
The symbol of the modern age—the computer—is of little use to Olshanskiy other than for checking e-mail and using the word processor, since today’s computers cannot tackle the problems he is working on. And that leads to perhaps the strangest fact about this field in which the 58-year-old Olshanskiy works: his theories might find practical applications 10 years from now, or maybe 20. “It’s normal for mathematical theories to be applied in practice 50 years after they were created,” he says. “Sometimes they are never used.”
Yet Olshanskiy seems unfazed by the uncertainty of it all as he walks 3.11 miles a day to work on theories that his children’s children might not see the fruits of and ponders eventual retirement back in Russia at his summer home. Even now, he’s content to go with the flow.
Batting Cleanup
Frank Parker
Professor, Civil and Environmental Engineering, Management of Technology
Vanderbilt University
Frank Parker came to Tennessee for one year to delay his search for a career path. Forty-eight years later, he’s still here. Now widely recognized as one of the world¹s top experts on nuclear waste, Parker was recruited to Oak Ridge National Laboratory (ORNL) to research ways in which the deadly byproduct of uranium and plutonium fissioning affects the environment. The year was 1956, barely a decade after the world¹s first nuclear bomb exploded in Alamogordo, New Mexico. Fresh out of a Ph.D. program at Harvard, the native Bostonian envisioned his involvement with nuclear waste as a short-term gig. Instead, he soon became the head of Radioactive Waste Disposal Research at Oak Ridge. In one project after another, he got involved with top-notch nuclear researchers who showed him the path to influence policies on nuclear waste disposal across the world.
At 77, Parker has crisscrossed the planet showing governments and private entities better ways of getting rid of nuclear leftovers, an especially troubling problem in Eastern European countries after the breakup of the Soviet Union. Left uncontrolled, piles of nuclear rubble can contaminate the environment and shorten lives of thousands of people. At times when local governments often are preoccupied with more basic needs, Parker seeks out funding from organizations worldwide and often serves as the main catalyst to cleanup efforts.
Throughout his career, Parker has authored books on novel methods of nuclear waste disposal, participated in classified negotiations and urged governments to change their often lenient ways of dealing with the dangers of nuclear waste. He often has had to be a diplomat to carry out his duty as a scientist. Among the few things he can recall on the record are negotiations in which he participated in Israel, when “everybody knew they were making [nuclear] weapons, but the discussion progressed as though there were no such efforts at all.”
The first ORNL scientist to start traveling extensively overseas, Parker is constantly on the go. In early February, he was the U.S. technical expert at the Moscow meeting of the Arctic Military Environmental Cooperation, outlining the hazards of towing decommissioned submarines. He has influenced decisions on nuclear waste disposal in China, Italy, Romania, Pakistan and Switzerland.
“I’ve always been willing to do things under uncertainty,” says Parker, who started out as a water resources engineer in Wyoming. At Vanderbilt University since 1967, he is also a senior fellow at the International Institute for Applied Systems Analysis in Austria, where he heads the Radiation Safety of the Biosphere program. Last year, Parker was awarded the Wendell D. Weart Award for Lifetime Achievement in Nuclear Waste Management, the top honor in the field. Despite his jovial demeanor, Parker is not all that optimistic about the survival of humankind. “In general, things are getting worse,” he points out, though he considers the biggest dangers to stem not from nuclear waste, but from the pressures of population growth. Nonetheless, Parker soldiers on optimistically with his nuclear cleanup efforts around the world.
“I think I keep going because I¹ve been radiated so much over the years,” Parker says.
The Plastic Age
Richard Turner
Research Fellow
Polymer Technology Division, Eastman Chemical
In the corporate laboratories of today, simply being a prodigious scientist doesn¹t suffice. To stay relevant in the eyes of many grant-giving, funds-distributing authorities, scientists often require a crash course in sales. Richard Turner, who holds 90 patents in polymer chemistry and has worked for such corporate giants as Xerox, Exxon Mobil and Kodak, points out that even in creating something as useful as a wheel one has to ask the question: Is the market ready for it?
Take 3M, a worldwide industrial giant, which recently had to restructure its laboratory to decrease the amount of scientific misses. “³They developed products the marketplace didn’t want,” Turner says.
Fortunately for Turner, the market seems ready for his inventions. Eastman Chemical now relies on Turner¹s research as the company moves to position itself firmly in the plastics markets of tomorrow. Creating new types of plastics that change properties when exposed to light, or plastic beer containers that better preserve the taste of the beverage, Turner says Eastman would be in the position to compete with General Motors, which is also committing substantial resources to plastics research.
With such a short deadline, Turner has his work cut out for him. But Eastman relies heavily on Turner¹s 30-year track record of successful inventions, such as hyperbranch and dendritic polymers, which he pioneered at Kodak. Those polymers earned him wide recognition for their flexibility and variety of industrial applications.
With its share price lagging the broad market in recent years, Eastman is looking to generate new divisions within the company that will improve its future standing. With $159 million in annual research spending, the company is lucky to have researchers like Turner who recognize entrepreneurs within themselves.
“I’m interested in developing new polymers and plastics that enable people to do things they can¹t do today,” Turner says.
In the marriage between business and technology, Turner has learned to be flexible in his experimentation. When projects fail, he moves on to another alternative, keeping his potential customers in mind.
The Nashville native and graduate of Tennessee Tech in Cookeville was awarded fellowship by the American Chemical Society for his contribution to the science and engineering of polymeric materials in 2002. When asked what his studies have revealed to him about the world, Turner responds: “You can’t fool Mother Nature."
Dead Men Talking
Arpad Vass
Forensic anthropologist
Oak Ridge National Laboratory
You won¹t convince Arpad Vass that a dead man tells no tales. Vass, a forensic scientist at Oak Ridge, runs the world’s only body farm—a place where corpses are left to rot on purpose for the sake of scientific research. For two decades, Vass has used his facility to extract ever more precise tales from the dead. Officially dubbed the Anthropology Research Facility, the 30-year-old plot of land on three wooded acres behind the medical center at the University of Tennessee, Knoxville was immortalized in Patricia Cornwell’s The Body Farm.
After arriving at the university in 1988, Vass, the son of a Hungarian immigrant, came under the wing of Body Farm creator William Bass (now retired). Since then, he has focused on developing a low-cost, easy-to-use method of determining time since death—a great boon for law enforcement agencies attempting to determine guilt and gain convictions. During his tenure at the farm, Vass says the margin of error in determining time since death has been reduced from weeks and months to plus or minus 12 hours.
In a world where a cadaver can be reduced to bare bones in as little as 30 days, weather permitting, Vass turns to outside objects, such as carpeting, bedding, or anything the body could be wrapped in. Analyzing the chemical makeup of the crime scene, he builds computer models of the body, figuring multiple variables, which ultimately lead to determining the coveted time since death.
Vass has seen it all. “We’ve had people dismembered, scattered around, sprayed with insecticide.” Vass and his colleagues use the UT Body Farm as an open-air laboratory where they can test the models they develop based on time-dependent chemical and biological markers to predict and analyze the decay process. Long since accustomed to the sight of rotting flesh, Vass admits one can never get used to the accompanying smell. “You just have to go with it.” The models Vass has created are currently being used in the United States, Canada, England and Australia. He has testified in some of the nation¹s gravest criminal cases, including the “Zoo Man” Huskey case in Knoxville and a Florida case where the perpetrators dragged the body from site to site in hopes of escaping punishment. His testimony there was based on the analysis of soil samples and led to a rare first-degree murder conviction reached without ever discovering the body.
But not all of Vass’ methods are purely scientific. Joking around with one of his visiting colleagues at the Body Farm, Vass once decided to use an equivalent of a divining rod to locate a buried corpse. Holding two pieces of a wire hanger in his hands, Vass was startled as he indeed found that body. “We laughed about it and tried again,” Vass says. The laughter died down after the divining method worked time and again, having never failed thus far. Vass is now devising a theory to support the experiment. “If you can use it on a nanoscale level in law enforcement, it would be a great tool,” he says. Also in Vass’ desk drawer is a technology of attaching electronic chips to flies, which are known to locate rotting flesh three miles away.
Be it by soil samples, divining rods or flies that spy, the dead are talking to Arpad Vass.
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